Capability
Downstream Purification
We develop and optimize purification processes to balance product purity, recovery and manufacturing efficiency.
SysGene supports downstream process development for monoclonal antibodies, Fc-fusion proteins and other recombinant proteins produced through microbial and mammalian expression systems. Each workflow is tailored to the molecule’s characteristics, the upstream process and the required product quality.
Our capabilities span primary recovery and clarification, affinity capture, chromatographic purification and polishing, alongside membrane-based concentration and buffer exchange. We optimize individual steps and their integration to reduce impurities, minimize product loss and simplify processing wherever feasible.
Analytical assessment guides development, helping us evaluate purity, aggregation, biological activity and recovery throughout the purification process. This connects process decisions with measurable product quality and performance.
Through defined operating conditions, process documentation and technical collaboration, we support reproducible purification workflows and their subsequent scale-up and transfer to customer or partner facilities.
